Benefits and Drawbacks of Transdermal Drug Delivery Systems
Transdermal Drug Delivery systems are the easiest way of ERT. There are some discomforts associated with this but its advantages outweigh the discomforts. Know about this in detail.
of Transdermal Drug Delivery systems
Transdermal drug delivery systems could
be unsuitable for drugs that irritate or sensitize skin.
The natural limits of drug entry imposed
by the skin's permeability indicates that relatively potent drugs are suitable
only for transdermal delivery.
Under various environmental conditions,
adhesions of the system to different skin types sometimes result in technical difficulties.
Advantages of Transdermal
Drug Delivery systems
Avoids gastrointestinal tract difficulties
during absorption caused by enzymes, drug interactions with food, etc.
Suitable in instances like vomiting/diarrhoea
where oral route is not desirable.
Avoids first pass i.e. the initial passage
of a drug substance through the systemic and portal circulation.
Provides the capacity for multi day
therapy with a single application thereby improving patient compliance.
Extends the activity of drugs having short half - life through the reservoir
of drug present in the delivery system and its controlled release characteristics.
Therapy can be quickly terminated by
removal of the patch from the skin.
Provides ease of rapid identification
of medication in emergencies - non-responsive patients, unconscious or
Less chances of over or under dosing
as the result of prolonged preprogrammed delivery of drug at the required
What is ETS
ETS is a new transdermal hormone
replacement therapy that is supposed to be convenient, safe, low dosage
estrogen therapy. It is a once-a-week dosage with a matrix patch,
and offers various benefits over the existing treatments:
Physiological low dose hormone
Avoids hepatic first pass
Convenient once a week treatment
Prevents and manages post-menopausal
symptoms - early symptoms like depression, anxiety, vaginal dryness, osteoporosis
and cardiovascular diseases.
this was not able to tell me the correct info i needed to do with hrt.
for research purpose
what about information on h.r.t with fertility.after loseing my 2nd pregnancy with i.v.f and h.r.t ,i thought i was safe with a succesful pregnancy taking h.r.t ,i was wrong, why? sarah.obrien@bi gpond.com.au
this is really a very informative article for the women passing through the phase of menopause.