Possible discomforts of Transdermal Drug Delivery systems
- Transdermal drug delivery systems could be unsuitable for drugs that irritate or sensitize skin.
- The natural limits of drug entry imposed by the skin's permeability indicates that relatively potent drugs are suitable only for transdermal delivery.
- Under various environmental conditions, adhesions of the system to different skin types sometimes result in technical difficulties.
Advantages of Transdermal Drug Delivery systems
- Avoids gastrointestinal tract difficulties during absorption caused by enzymes, drug interactions with food, etc.
- Suitable in instances like vomiting/diarrhoea where oral route is not desirable.
- Avoids first pass i.e. the initial passage of a drug substance through the systemic and portal circulation.
- Provides the capacity for multi day therapy with a single application thereby improving patient compliance. Extends the activity of drugs having short half - life through the reservoir of drug present in the delivery system and its controlled release characteristics.
- Therapy can be quickly terminated by removal of the patch from the skin.
- Provides ease of rapid identification of medication in emergencies - non-responsive patients, unconscious or comatose patients.
- Less chances of over or under dosing as the result of prolonged preprogrammed delivery of drug at the required therapeutic rate.
What is ETS
ETS is a new transdermal hormone replacement therapy that is supposed to be convenient, safe, low dosage estrogen therapy. It is a once-a-week dosage with a matrix patch, and offers various benefits over the existing treatments:
- Physiological low dose hormone
- Avoids hepatic first pass
- Convenient once a week treatment
- Prevents and manages post-menopausal symptoms - early symptoms like depression, anxiety, vaginal dryness, osteoporosis and cardiovascular diseases.
You may also be interested in:
- The Indiaparenting Team