Transdermal Drug Delivery systems are the
easiest way of ERT. There are some discomforts associated with this but its
advantages outweigh the discomforts. Know about this in
detail. Transdermal drug delivery is done
with the help of a transdermal patch. This transdermal patch is a medicated
adhesive that helps to transfer a particular dosage of medication into blood
stream through skin. Therefore, this patch is required to place on the skin of
the patient. It helps in the recovery of the affected part of the body. Let us
take a look at the advantages and disadvantages of transdermal
drug delivery systems.
Possible Discomforts of Transdermal Drug Delivery
Here are some of the
possible discomforts of transdermal drug delivery
- Transdermal drug delivery systems could be unsuitable
for drugs that irritate or sensitize skin.
- The natural limit of drug entry
imposed by the skinâ€™s permeability indicates that relatively potent drugs are
suitable only for transdermal delivery.
- Under various environmental
conditions, adhesions of the system to different skin types sometimes result in
Advantages of Transdermal Drug Delivery
Have a quick look at the
advantages of transdermal drug delivery
- Avoids gastrointestinal tract difficulties during
absorption caused by enzymes, drug interactions with food, etc.
- Suitable in instances like
vomiting/diarrhoea where oral route is not desirable.
- Avoids first pass i.e. the initial
passage of a drug substance through the systemic and portal
- Provides the capacity for multi
day therapy with a single application thereby improving patient compliance.
Extends the activity of drugs having short half - life through the reservoir of
drug present in the delivery system and its controlled release characteristics.
- Therapy can be quickly terminated
by removal of the patch from the skin.
- Provides ease of rapid
identification of medication in emergencies - non-responsive patients,
unconscious or comatose patients.
- Less chances of over or under
dosing as the result of prolonged pre-programmed delivery of drug at the
What is ETS?
ETS is a new transdermal
hormone replacement therapy that is supposed to be convenient, safe, low dosage
therapy. It is a once-a-week dosage with a matrix patch,
and offers various benefits over the existing treatments:
How Does Transdermal Drug Delivery Systems
Transdermal drug delivery system
is very simple to use and can be effectively administered. Skin is one of the
largest organs of human body. It is a protective layer on the body which covers
the entire body. It has the capability to redevelop and it provides crucial but
limited penetration. This kind of permeation that skin provides is very
important for transdermal drug delivery systems to
Skin is a three-layered protective
cover on the body. The first layer is known as epidermis on which the transdermal
patch is placed. The patch is placed in such a way that the side of the patch
that contains medicine is in contact with the first layer of skin (epidermis).
When the medicine from the patch reaches the second layer of skin, it then
transfers it to the third or the deepest layers of skin. This last and the
deepest layer of skin contain blood vessels which then pass the medicine into
the blood stream.
The medicine from the patch
penetrates through the three layers of skin and reaches the blood stream via
blood vessels. In this way the medicine that is transferred into the blood is
circulated in the patientâ€™s body through the circulatory system. In this way
the medicine is directly circulated in the blood stream of patient.