Hormone Replacement Therapy is very effective in treating menopausal symptoms. The principal hormones used in HRT are estrogen and progesterone. This therapy reduces the risk of osteoporosis, heart attacks and strokes.
What is Hormone Replacement
All menopausal and post-menopausal
women go through estrogen deficient years, which can manifest in both physical
and emotional ways leading to impairment of the quality of life.
As the female life expectancy has increased, it is possible for a woman
to live one third of the life after menopause. Hormone Replacement Therapy (HRT) is a treatment for menopause given to women to correct the hormonal
deficiency in peri- and post-menopausal state.
Which hormones are
used in HRT
The principal hormones used in HRT
are estrogen and progesterone. There are two types of estrogen available:
synthetic and natural.
Synthetic estrogens: Synthetic
estrogens give rise to substances in the plasma which have potent estrogenic
activity but which are structurally dissimilar to the estrogens produced
by the ovary. Examples include ethinyl estradiol, mextranol and stilboestrol.
Synthetic estrogens, as prescribed in the oral contraceptive, exert a pharmacological
Natural estrogens: Natural estrogens,
on the other hand, give rise in plasma to estrogens which are identical
to those produced by the pre-menopausal ovary e.g. estradiol, estrone and
estriol. These get classified by route of administration i.e. oral or vaginal.
What is the scientific
basis of HRT
The problems associated with menopause
are due to the deficiency of a female hormone called estrogen. These problems, therefore, can largely be prevented by estrogen replacement therapy (ERT). ERT reduces the incidence of osteoporosis, heart attacks,
strokes and generally improves the well being and life span of women. For
more than three decades estrogens have been prescribed to relieve menopausal
symptoms. Treatments like Estrogen Replacement Therapies (ERT) and Hormone
Replacement Therapies (HRT) can reduce the gynecological and psychological
changes associated with menopause while inhibiting bone resorption and reducing the risk of cardiovascular diseases.
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