Administering HRT with Transdermal Drug Delivery Systems
HRT is an effective method of easing the menopausal symptoms. Administration of HRT can be oral, parenteral, rectal, vaginal, topical and transdermal. Transdermal Drug Delivery is done through application of patches containing drug to skin. Know more about this method of application.
How is HRT administered
There are various ways of administering
HRT. Some of them include: oral, parenteral, rectal, vaginal, topical and transdermal (through the skin). These treatments can also be classified
as oral, percutaneous and transdermal.
What are transdermaldrug delivery systems
Transdermal (through the skin) drug
delivery system is one way of administering HRT. Other methods of
administering HRT include oral, parenteral, rectal, vaginal and topical.
Transdermal applicators are the patches
containing the drug. They are flat, smooth, discrete and can be used
for long term medication. Transdermal delivery systems are not just an
alternative route of administration but they improve the therapeutic value
of a drug and provide many other advantages including increasing compliance.
Transdermal therapy could be of two
types: (a) Reservoir type: Those that control the rate of drug delivery
to skin; and (b) Matrix type: Those that allow the skin to control rate
of drug absorption.
Why is skin the site
for transdermal drug delivery
Skin is one of the most readily accessible
organs of the human body. It has a thickness of only a few mm. Skin
is a multi-layered organ composed of many histological layers. Its
three main layers are: the epidermis, the dermis and the hypodermis.
The epidermis is further divided
into 5 anatomical layers. The outermost layer is the stratum corneum which
is exposed to external environment. The transdermal permeation of neutral
molecules at steady state can be considered as a process of passive diffusion
through the stratum corneum in the interfollicular region.
for the use of TransdermalDrug Delivery systems
The site selected for application should
be clean dry and hairless e.g. estradiol patches are applied to buttocks
or abdomen, nitroglycerine patches are applied to chest. Scopolamine behind
ear. Because of possible occurrence of skin irritation, sites of application
for patches are rotated weekly.
Transdermal patch should not be applied
to skin that is already irritated or act so as to ensure maximum absorption.
Patches should be removed from its protective
package being careful not to tear or damage patch. Protective backing should
be removed to expose the adhesive layer and it should be applied firmly
with the palm of the hand until it is secured in place.
Patches may be left on when bathing
or swimming. If the patch gets dislodged one must re-apply it or it may
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