testing for celiac disease which is an autoimmune disorder requires a swab
sample from the mouth or a blood sample. This testing can accurately predict
the risk probability of the celiac disease along with the statistical
probability of the individual’s offspring inheriting the same risk. A severe
celiac disease is found to occur if both the parents are carriers of this gene.
The testing also includes gluten sensitivity.
How are the Results Interpreted?
are two high risk genetic patterns: DQ2 and DQ8. If any portions of these two
variants are absent, it means there is almost no probability of celiac disease
occurring in that individual. Such a result is considered to be 99.9% accurate.
There is another genetic
testing for this disease which is known as negative celiac genetic testing.
lot of clinicians are apprehensive about its efficacy due to a large number of
cases that point out its ineffectiveness. The accuracy of negative celiac
genetic testing solely depends upon the entire HLA DQ pattern, inclusive of
both the alpha and beta subunits. Both the DQ2 and DQ8 genetic patterns have
alpha and beta subunits. But the inaccuracies of the genetic tests
are due to the fact that only the beta subunit is tested by most clinics.
DQ typing is a very complicated procedure. So much so, even the scientists and
physicians have a tough time in apprehending the genetic findings. So in most
of the cases the genetic testing reports do not contain all the relevant
information and even if they are present, they are not adequately considered.
sensitivity or intolerance cannot be ascertained through the absence of DQ2 and
DQ8 in the celiac genetic testing reports. The DQ2 and DQ8 are basically
genetic white blood cell patterns. It is important to understand that both the
two variants are necessary in order to contract the celiac disease. There is a
new study that tells us that a negative celiac genetic testing cannot rule out
the possibility of celiac disease, particularly in men.
Facts of Celiac Genetic Testing
are some important facts on genetic testing for celiac disorder.
Determines Risk to Individual and His
- The genetic tests can offer extensive information on both the individual and
his offspring’s risk.
It is Complex Test - It is rather
peculiar to this genetic test that the doctor may not be aware of this genetic
test or be unsure on when to suggest and even fail to interpret the reports,
given the complexity of the genetic test.
Type of Diet does not Impact this Test - There is no
impact of the type of diet
in this test. Since there is a gluten sensitivity test, it does not mean that a
pro-gluten or gluten free diet will have any impact on the test results. But while
testing for the celiac disease antibodies, one should follow a pro-gluten
Insurance Coverage is Limited - A lot of insurance
companies do not offer any coverage for celiac genetic testing. Here are some
diagnostic codes that can prove to be helpful while you are considering an
insurance coverage – 579.0 (for celiac disease) and V84.89 (for genetic
susceptibility for the same disease).
Accuracy of the Test - As said
earlier, the accuracy of the genetic test depends on the testing of both the
alpha and beta subunits. So it is important that when you are given a negative
genetic test report, make sure that it is not simply a beta typing and you have
been tested for the alpha and beta subunits of the HLA DQ.
Findings of the Test - If the person
tested is a man, you need to take note of the fact that a negative genetic test
might exclude the possibility of the occurrence of celiac disease just like a
negative blood test. If the man happens to be of an advanced age and has been
suffering from a ling standing severe disease, it is more likely that they
would have a negative genetic and blood
disease can be called gender specific as a man’s risk of having the disease is
higher compared to the woman particularly if the classic growth pattern is
absent in her. Then there is a possibility of the blood test being negative
too. But the probability heightens of the woman inherited the risk gene from
her father instead of her mother.