MHC is considered to be a very convenient option for
depending on the manner in which it is delivered and the frequency of the
dosage. Read on to know more about the method of delivery of MHC, its side
effects and reversal.
Method of Delivery of MHC
MHC involves the administration of androgens and it
becomes effective only after it is injected into the muscle. One needs to visit
a clinic in order to receive this intramuscular shot
only from an experienced nurse or physician. The formulation can be injected
every two three months.
If the injections are administered in an infrequent
manner, it might well result in a lack of effectiveness and there might also be
certain side effects. These effects are caused due to the fluctuating and
patchy levels of androgen. The amount of active androgen in the blood stream
causes all the havoc.
It is vital to ensure that the testosterone levels
are even. So an injection is usually followed by a spike. This results in the
return of the sperm
in the ejaculation.
Due to these side effects researchers are
considering viable alternative to MHC injection. They are investigating the
effectiveness of implants, pills, patches and even creams. Implants can be
active for several months at a stretch and the androgen levels can remain
steady all through out. They are placed in and removed with the aid of a minor
surgery. The only risk involved is its possibility of breaking the skin above
it and that too a minor 3-7% one. But the other four that is pills, patches and
creams have not been able to deliver satisfactory outcomes.
Side Effects of MHC
There can be a wide array of side effects that can
vary in men going for MHC. Some of the common ones are:
weight gain in the lean muscle mass of the body
possible breakout of acne
Doctors opine that these side effects are actually
attributed the synthetic androgen present in the MHC dose. These can also be
easily minimised by effective tailoring of the androgen dosage and the manner
in which it is delivered. But just like the known side effects of the female
contraceptive pill, the MHC will also have certain side effects that cannot
be totally done away with.
Another side effect that can be of concern follows
from the deliberate alteration of the process of androgen metabolism in the
man. It is depressed to high density lipoprotein cholesterol or HDL-C. It
becomes a constituent of the blood and this is basically regarded as the
healthy variety of cholesterol that also correlates with lowering the danger of
atherosclerosis that is where the arteries get hardened.
So this is of course not desirable if the levels are
depressed. In clinical trials it has been observed that the drop is as mush as
15%. This side effect cannot be completely eliminated and men, who stand the
risk of heart diseases, are advised against using the MHC.
Screening is also on to test the effect of the MHC
on the prostrate gland of the man.
Reversal Period for MHC
The effects of the MHC contraceptive can be reversed
within a period of 4-6 months. After the treatment is stopped, the body resumes
in making the hormones at a level that was there during the pretreatment state.
After the restoration of the hormones, the first immature sperm is produced in
the seminiferous tubules. The sperm becomes completely functional within two
and half months.
It is interesting to note that some men may not
respond to MHC and researchers are not well equipped with a viable explanation
to this. The formulation and the delivery method are the presumed factors that
cause around 5-20% men during the trials to remain ineffective to MHC. It has
also been observed that men with higher body mass (fat) are the common