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Fertility Issues Topics..

You are here : home > Fertility Issues > Recent Advances in Medicine > GIFT A Life




GIFT stands for gamete intrafallopian transfer. A gamete is a male or female sex cell --- a sperm, or an egg. During GIFT, sperm and eggs are mixed and injected into one or both fallopian tubes. After the gametes have been transferred, fertilization can take place in the fallopian tube as it does in natural, unassisted reproduction. Once fertilized, the embryo travels to the uterus by natural processes.

As in IVF, a GIFT treatment cycle begins with ovulation enhancement which is followed by egg harvest, usually by means of laparoscopy. But the similarity to IVF ends here. In IVF, an embryo is transferred. In GIFT, gametes are transferred.

Only patients who have at least one normal, healthy fallopian tube are candidates for GIFT. Such patients include women who have unexplained infertility or mild endometriosis and couples whose infertility results from male, cervical, or immunological factors. Some doctors recommend that couples with male factor infertility proceed with GIFT only if it has been proven that the man's sperm can fertilize the woman's egg either by in vitro fertilization or by past pregnancies.

The Basic Steps of GIFT

The basic steps of GIFT are ovulation enhancement, egg harvest, insemination, and gamete transfer. The eggs are usually harvested during laparoscopy. During this same laparoscopy procedure, which takes about an hour, eggs are mixed with sperm and the gametes are transferred.


The harvested eggs are examined under the microscope and graded for maturity. The selected eggs are placed in individual dishes and combined with sperm (insemination). The sperm are prepared in advance in the same manner as for IVF. Some doctors prefer to wait for about 10 minutes before the transfer, since during this period the sperm adhere to the zona pellucida of each egg. Many programmes load eggs and sperm individually into a catheter and inject them into one or both of the fallopian tubes.

Gamete Transfer

The sperm - egg mixture is loaded into a specially designed catheter . This is then directed into the fallopian tube(s) through their fimbrial opening while looking through the laparoscopy. Up to four eggs and sperm may be injected into one or both tubes. Gametes will be transferred only if the fallopian tubes appear healthy. If the surgeon determines that the tubes are unhealthy, IVF should be attempted instead. For this reason, GIFT should be undertaken only at facilities that have the capability to perform IVF also.

Pregnancy Rate

Specialists generally agree that pregnancy rates are higher for GIFT than for IVF - in fact, GIFT is about twice as successful as IVF. In part, this may be due to the type of patient accepted into GIFT programmes. It may also be because the in vivo tubal environment is more "physiologic " for the gametes and embryo than the in vitro environment.

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haleema khatoon
haleema khatoon.10 years ago
i have done one ivf in one of the best clinic in hyd but its failed . my both follipion tubes are damage because of tuberculosis . please advice me , iam 27 years old .
haleema khatoon
haleema khatoon.10 years ago
how can i have g i f t like my both tubes r complitly damage it cannot be open .
Dolly.10 years ago
hi, can i get some contact information for dr. nayna patel of akanksha infertilty clinic at anand, gujarat. would be really grateful for your help.

rajani.10 years ago
married since 6yeras but did not concieve even once reports appears to be normal .please help me as to what should i do
suhas.10 years ago
hi,i am married since 5years and my wife did not concieve yet our reports aer normal but we are unabe to get a child what do we do . does a man being bisexual effects in any way to get a child please help me with this my spearm count is normal.
neeru.10 years ago
can anyone tell me about dr. anuradha, because i want to go for ivf. and i want to know how much she is going to charge per cycle
neeru.10 years ago
when is the right time to go for ivf, is it right in summer or winter or anytime
rambo.10 years ago
can i get email account of dr indira hinduja
Bhavesh soni
Bhavesh soni.10 years ago
married since 6yeras but did not concieve even once reports appears to be normal .please help me as to what should i do , i want option about test tube baby how it.
pittu.10 years ago
please let me know good ivf clincs in hyderabad and approximate cost
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