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Due Date Club January 2007:For Pavan
2006-06-29
Name: archie



Pavan
Appended below is my message to Shikha from November 2006 board. her case is as follows she is Rh+ve and her spouse is Rh-ve. She had a hydrops fetalis but you will learn that was not from Rhesus incompatibility but from over dose and treatment of unsafe drug in her first trimester.

Rhesus comptability is not an issue if both spouse are Rh-ve, or Rh+ve, also for mother Rh+ve and spouse Rh-ve. It can be a threat and concern for those mothers-to-be are Rh-ve (lack of antigen D on her erythrocytes) and spouse if Rh+ve (carrying antigen D on his erythrocytes). In this case there is a 50% possibility that baby growing in uterus carries d-agntigen on the erythrocytes and when fetal-maternal blood exchange takes place, usually after 26 weeks of gestation mothers body start producting antibodies against the antigenD. These antibodies are less likely be of concern to first baby if at all it will have some anemia but if second baby is also Rh+ve then developed antibodies from earlier pregnancy can cross through the plancenta and can lead to severe anemia, leading to hydrops foetalis of second baby.

you both are B+ve and you will expect your baby to be B+ve and should have no concern at all for this and later pregnancies.
archie
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Shikha,
I am sure you will get this confirmed from both your OB and your aunt.

---- you won't need to worry about Rh-ve and condition referred to as 'rhesus incompatibility'. Your first baby you lost due to *Hydrops foetalis* has nothing to do with rhesus incompatibility below is my explanation:
Rhesus incompatibility when mother is Rh-ve and father is Rh+ve, that has 50% chances for baby to be Rh+ve. If the first baby is Rh+ve then during child birth your body get sensitised and starts producing anti-RhD antibodies and thereby any baby in future pregnancy with Rh+ve blood group will face two major concerns 1. Severe anemia or Hydrops foetalis.
However the one you lost in 7th month was your first baby and not expected to have rhesus incompatibility as a culprit.
yes, two reasons for blaming Norflox. one a contraindicated drug and second the amount of time you were prescribed. I know usually it's 7-10days depending on strength of infection. first time I heard someone was treated with Norflox for 21 days. Not that if you were treated for 10 days would have saved baby. I suspect this treament might have led to maldevelopment of fetus and resulted in loss.


-----Rhesus incompatibility is concern for the mother with Rh-ve antigen and not Rh+ve mothers. Since you are Rh+ve you won't have to worry for Rhesus incompatibility.

Archie


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2006-07-03
#1
Anonymous Name: Pavan
Subject:  Thanks a lot for your assurance



Thanks a lot Archie.
I am pretty relieved and relaxed now. Thanks again :)

Regards
Pavan
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