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Pregnancy Topics..

You are here : home > Pregnancy > Medical Aspects of Pregnancy > Ergometrine


Ergometrine Drug is used to reduce post-partum haemorrhage but has to be used with caution. Read on to know the effects of Ergometrine Drug during pregnancy.

Ergometrine induces uterine contraction and may therefore cause premature labour.  Products containing Ergometrine should therefore be avoided as far as possible during pregnancy.

Ergometrine is an ergot alkaloid, which contains ergopeptines, also known as ergopeptides. It is used for the active management of the third stage of labour. The third stage of labour starts from the time of the delivery of the baby and ends at the time of the delivery of the placenta. It is known to prevent and control bleeding after childbirth, which is called post-partum haemorrhage.

Who Should and Who Should Not Get Ergometrine and When?

Ergometrine injection is restricted to be used only during the third stage of labour. It is banned to be used during the first or second trimester of pregnancy. Also, it is asked not to be used during the lactation period. It is usually not recommended to be used if the pregnant woman is suffering with a known hypertension, including pre-eclamptic toxemia.

If the pregnant lady is having occlusive vascular disorders or renal failure or sepsis or severe cardiac liver, usage of Ergometrine is usually not preferred. Patients with preeclampsia, eclampsia or threatened spontaneous abortion or porphyria should not be given Ergometrine.

How Is the Ergometrine Administered?

Ergometrine injection is used during the third stage of labour and in the treatment of post-partum haemorrhage. It may be given intramuscularly or intravenously. It is administered at or immediately after delivery of the baby. Ergometrine is usually given in combination with oxytocin (Syntometrine), which is also known to help the uterus to contract.

How Does Ergometrine Work?

Three different types of receptors found in the blood vessel walls and the uterus walls are stimulated by Ergometrine. This constricts the blood vessels and contracts the uterus. The contractions help in speed delivery of the placenta, and after the placenta comes away, it helps in reducing the risk of heavy bleeding. The blood flow to the uterus is reduced, which thus helps to reduce blood loss as the placenta is pushed out from the wall of the uterus.

Use in Pregnancy

There is evidence of foetal abnormalities or foetal risk while using Ergometrine during pregnancy. Ergometrine causes uterine contraction and may cause premature delivery of the baby or labour with an increased pressure, commonly known as hypertonic labour. Tetanic contractions may result in foetal distress and reduced blood flow of the uterus. So, products containing Ergometrine should be avoided as far as possible during pregnancy.

Ergometrine is secreted in breast milk. Use of multiple doses of Ergometrine in postpartum patients is known to lower prolactin levels and suppress lactation and chronic ergot toxicity can also be caused in the baby if one uses it for a long time. Therefore, Ergometrine is also contraindicated during lactation.

Precautions for Using Ergometrine

Ergometrine may give rise to widespread vasoconstriction, which causes the contraction of the blood vessels resulting from the constriction of the muscular wall of the vessels, particularly the large arteries and small arterioles. Ergometrine can also cause acute pulmonary oedema, which cause problems in breathing leading to poor oxygenation of blood as the alveoli fill up with excess fluid coming out of the blood vessels in the lung instead of air.

The sudden constriction of blood vessels induced by Ergometrine can also lead to heart attack in pregnant ladies with coronary artery disease. Also, special care should be taken if Ergometrine is administered to pregnant women having known hypertension or sepsis or Raynaud's disease.

If bleeding is not arrested by the Ergometrine injection in the treatment of postpartum haemorrhage, it is not recommended to use a second-time injection of the drug. There could possibly be chances of placental fragment being retained, injury of soft tissue, either vaginal or cervical or defects related to clotting. Appropriate measure and special care should be exercised before injecting this drug again. Seek further medical advice from your doctor or midwife if you face more issues.

When is Ergometrine Drug used? What precautions are to be considered while administering this drug? When to avoid administration of Ergometrine Drug? Discuss here.

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Jeevan.5 years ago
could not understand what this article is all about....
Shahnaaz.5 years ago
give more details...
vaausidf.8 years ago
ia want
rinu.8 years ago
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