While modern technology is very good at making embryos in the laboratory, we still cannot control the implantation process. We do not know which embryo will become a baby - and this can be very frustrating, for both patients and doctors.However, you need to remember that embryo implantation consists of a series of phases in which the embryo has to appose and attach itself to the maternal endometrium and invade into it.The enigma of embryo implantation - why doesnt every embryo become a baby? While modern technology is very good at making embryos in the laboratory, we still cannot control the implantation process. We do not know which embryo will become a baby - and this can be very frustrating, for both patients and doctors! Many patients who do not get pregnant after an embryo transfer start believing that their bodies are defective, and that they have "rejected" the embryo. They feel that if they failed to become pregnant even after the doctor transferred 3-4 good quality embryos, that they are flawed. However, you need to remember that embryo implantation is a very complex process, which consists of a series of phases in which the embryo has to appose and attach itself to the maternal endometrium and invade into it. First, the embryo has to undergo further development, till it reaches the blastocyst stage, when it hatches from its shell, known as the zona. The hatched blastocyst then needs to implant in the endometrium. This occurs during the period of time known as the implantation window. Apposition, or orientation of the embryo (which is at the blastocyst stage at this time) within the cavity of the uterus, starts when the cavity has become minimal due to the suction of endometrial fluid by pynopods (small protrusions found on the surface membrane of the cells lining the uterus). Adhesion of the blastocyst is a progressive phenomenon that ties the embryo to the endometrium and is the primary event initiating invasion. Many molecules, such as cytokines, growth factors and cell adhesion proteins called integrins play an important role in this complex process during which the blastocyst and maternal endometrium must undergo an exquisite dialogue. Invasion is a self-controlled proteolytic process that allows the embryonic trophoblast to penetrate deep into the maternal decidua and to invade the endometrial spiral arteries by producing chemicals called proteinases. How implantation is regulated and brought about remains an enigma, but we need to remember that the implantation process is surprisingly inefficient in humans - Nature is not always very competent! After IVF, its only about 10%, which means that only 10% of embryos implant successfully to become a baby. The responsibility for this low efficiency has to be shared between the embryo the endometrium, as well as a defective embryo-endometrium dialogue. We still cannot successfully predict which patient will get pregnant after embryo transfer. We now know that one of the major reasons for failure of the embryo to implant is a genetically abnormal embryo. Basic research on implantation is of great interest today, because embryonic implantation is the major limiting factor in allowing pregnancy after ART, but we still need to learn a lot about this "black hole" in our knowledge, before we can learn to control it ! Some clinics attribute failure of the embryos to implant to immunological problems - and even offer "treatment" for this, but there is no proof to support this theory. Remember, embryo implantation is a complex process, which you cannot influence by your diet or physical activity, so there is no need for you to blame yourself if the embryos do not implant.
While modern technology is very good at making embryos in the laboratory, we still cannot control the implantation process. We do not know which embryo will become a baby - and this can be very frustrating, for both patients and doctors.However, you need to remember that embryo implantation consists of a series of phases in which the embryo has to appose and attach itself to the maternal endometrium and invade into it.
The enigma of embryo implantation - why doesn't every embryo become a baby?
While modern technology is very good at making embryos in the laboratory, we still cannot control the implantation process. We do not know which embryo will become a baby - and this can be very frustrating, for both patients and doctors!
Many patients who do not get pregnant after an embryo transfer start believing that their bodies are defective, and that they have "rejected" the embryo. They feel that if they failed to become pregnant even after the doctor transferred 3-4 good quality embryos, that they are flawed. However, you need to remember that embryo implantation is a very complex process, which consists of a series of phases in which the embryo has to appose and attach itself to the maternal endometrium and invade into it.
First, the embryo has to undergo further development, till it reaches the blastocyst stage, when it hatches from its shell, known as the zona.
The hatched blastocyst then needs to implant in the endometrium. This occurs during the period of time known as the implantation window.
Apposition, or orientation of the embryo (which is at the blastocyst stage at this time) within the cavity of the uterus, starts when the cavity has become minimal due to the suction of endometrial fluid by pynopods (small protrusions found on the surface membrane of the cells lining the uterus).
Adhesion of the blastocyst is a progressive phenomenon that ties the embryo to the endometrium and is the primary event initiating invasion. Many molecules, such as cytokines, growth factors and cell adhesion proteins called integrins play an important role in this complex process during which the blastocyst and maternal endometrium must undergo an exquisite dialogue.
Invasion is a self-controlled proteolytic process that allows the embryonic trophoblast to penetrate deep into the maternal decidua and to invade the endometrial spiral arteries by producing chemicals called proteinases. How implantation is regulated and brought about remains an enigma, but we need to remember that the implantation process is surprisingly inefficient in humans - Nature is not always very competent! After IVF, it's only about 10%, which means that only 10% of embryos implant successfully to become a baby. The responsibility for this low efficiency has to be shared between the embryo the endometrium, as well as a defective embryo-endometrium dialogue. We still cannot successfully predict which patient will get pregnant after embryo transfer. We now know that one of the major reasons for failure of the embryo to implant is a genetically abnormal embryo. Basic research on implantation is of great interest today, because embryonic implantation is the major limiting factor in allowing pregnancy after ART, but we still need to learn a lot about this "black hole" in our knowledge, before we can learn to control it ! Some clinics attribute failure of the embryos to implant to immunological problems - and even offer "treatment" for this, but there is no proof to support this theory.
Remember, embryo implantation is a complex process, which you cannot influence by your diet or physical activity, so there is no need for you to blame yourself if the embryos do not implant.
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- The Indiaparenting Team
I want to give my deepest gratitude and love to the most deserving and hardworking doctor, who has enlightened my life with two beautiful angels,..... Dr. Kaberi , we respect you from the bottom of my heart,.. you are the only one at that point of time who encouraged me and my husband that this is not the end of our lives, she was always optimistic about our case... and inspite of so hopelessness and pain we were through we decided to go ahead with it for the last time and now we are blessed with twin angels... love you doctor, may god bless you and your family......
I want to thank Dr. Anoop Gupta and the entire staff at Delhi IVF for the great service and support they gave us during our most difficult times. With their help i have completed my dreams and enjoy every moment of my life with my daughter "Adya", who turns 2 tommorow. Thank you for being the special people in my life.
I wanted to share a few thoughts about my doctor. For months I was facing a problem with getting pregnant until we finally gave up hope. They say when all doors are closed, a window of hope opens up. And I met Dr. Archana through a referral. My experience has been incredible and I got such personal attention from her. My case from different than others & I never had imagined conceiving. It finally happened and I became a mother. I can't thank you enough Doctor. Regards, RK.
We are very glad to tell u that our home has grown by four feet, words cannot xpress enough how grateful we are for everything you have done for us………. In helping the BEST gift of our lives…. “our twin babies”.
The twins are doing fantastic. First twin weighs 5pounds 10 ounce and Second twin weighs 6pounds 1 ounce.
Thank u for being perfect doctor for me… I will always keep u in my prayers.
Dr. Kaberi is like God for us, its because of her dedication towards our case and hard work that , on 12th Dec Pallavi give me the greatest gift (baby girl)which has been possible with your wish and help. Me and pallavi are thankful to u. When we will come back to Delhi we will meet you with our baby girl.
Dr. Kaberi Banerjee is the best doctor i have ever met. We cannot thank her enough for the priceless gift which she had given us. I can say dat we have not seen God but god always sent an angel for such people lyk us. We will pray for her and her loving family also. Thanx is not enough to god bt I dare to say thanx to god also. No words to xpress our feelings and thnx.
We love u and yes. You are not only good Dr. but also a very very Kind and soft heart Human being. We must say in 2days world nicenice persons are rare but we have with us. You are a real GEM you deserve our best salute.
I am currently undergoing IVF with Dr Archana Dhawan Bajaj. She is the best doctor I have met (and I have met a lot of doctors) She is very good natured and a good person and a brilliant doctor. She is in Adiva Hospital in Uday Park in South Delhi. I recommend her to everyone who is suffering from infertility. Please do not ever go to Phoenix Hospital in GK2 for infertility treatment. That place is very commercial and very poor in diagnosis.
I had a success at Moolchand hospital.I was suffering from unexplained infertility since years and was very depressed changing doctors every time. The fertility team at Moolchand is excellent,they help me get out of all the stress and here I am now happy with their results. I highly recommend this centre to all those suffering like me.