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Benefits
and Drawbacks of
Transdermal
Drug Delivery Systems
Possible discomforts
of Transdermal Drug Delivery systems
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Transdermal drug delivery systems could
be unsuitable for drugs that irritate or sensitize skin.
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The natural limits of drug entry imposed
by the skin's permeability indicates that relatively potent drugs are suitable
only for transdermal delivery.
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Under various environmental conditions,
adhesions of the system to different skin types sometimes result in technical
difficulties.
Advantages of Transdermal
Drug Delivery systems
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Avoids gastrointestinal tract difficulties
during absorption caused by enzymes, drug interactions with food, etc.
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Suitable in instances like vomiting/diarrhoea
where oral route is not desirable.
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Avoids first pass i.e. the initial passage
of a drug substance through the systemic and portal circulation.
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Provides the capacity for multi day
therapy with a single application thereby improving patient compliance.
Extends the activity of drugs having short half - life through the reservoir
of drug present in the delivery system and its controlled release characteristics.
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Therapy can be quickly terminated by
removal of the patch from the skin.
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Provides ease of rapid identification
of medication in emergencies - non-responsive patients, unconscious or
comatose patients.
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Less chances of over or under dosing
as the result of prolonged preprogrammed delivery of drug at the required
therapeutic rate.
What is ETS
ETS is a new transdermal hormone
replacement therapy that is supposed to be convenient, safe, low dosage
estrogen therapy. It is a once-a-week dosage with a matrix patch,
and offers various benefits over the existing treatments:
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Physiological low dose hormone
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Avoids hepatic first pass
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Convenient once a week treatment
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Prevents and manages post-menopausal
symptoms - early symptoms like depression, anxiety, vaginal dryness, osteoporosis
and cardiovascular diseases.
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