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What is HRT

What is Hormone Replacement Therapy (HRT)

All menopausal and post-menopausal women go through estrogen deficient years, which can manifest in both physical and emotional ways leading to impairment of the quality of life.  As the female life expectancy has increased, it is possible for a woman to live one third of the life after menopause. Hormone Replacement Therapy (HRT) is a treatment for menopause given to women to correct the hormonal deficiency in peri- and post-menopausal state.
 

Which hormones are used in HRT

The principal hormones used in HRT are estrogen and progesterone. There are two types of estrogen available: synthetic and natural. 

  • Synthetic estrogens: Synthetic estrogens give rise to substances in the plasma which have potent estrogenic activity but which are structurally dissimilar to the estrogens produced by the ovary. Examples include ethinyl estradiol, mextranol and stilboestrol. Synthetic estrogens, as prescribed in the oral contraceptive, exert a pharmacological effect. 
  • Natural estrogens: Natural estrogens, on the other hand, give rise in plasma to estrogens which are identical to those produced by the pre-menopausal ovary e.g. estradiol, estrone and estriol. These get classified by route of administration i.e. oral or vaginal.


What is the scientific basis of HRT

The problems associated with menopause are due to the deficiency of a female hormone called estrogen.  These problems, therefore, can largely be prevented by estrogen replacement therapy (ERT).  ERT reduces the incidence of osteoporosis, heart attacks, strokes and generally improves the well being and life span of women. For more than three decades estrogens have been prescribed to relieve menopausal symptoms. Treatments like Estrogen Replacement Therapies (ERT) and Hormone Replacement Therapies (HRT) can reduce the gynecological and psychological changes associated with menopause while inhibiting bone resorption and reducing the risk of cardiovascular diseases.
 

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