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Non-steroidal, anti-inflammatory drugs (NSAID, example: brufen) Ibuprofen When taken at term, they prolong
labour. Therefore these products are best avoided late in pregnancy.
Rheumatism drugs (Antirheumatic) Because of the long half-life of an anti-rheumatic drug called amiodarone and its major metabolite, there is a potential for it to cause abnormal thyroid function and bradycardia in the fetus. For this reason, its use is best avoided in the three months before and throughout the duration of pregnancy. Where exposure of the fetus is unavoidable, thyroid function (including TSH) should be assessed promptly in the neonate. High doses of quinine (and quinidine) also causes fetal injuries in the form of deafness, developmental disturbances and malformations of the extremities and cranium. Its ability to induce uterine contractions also leads to a risk of abortion.
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