Drug: Human Chronic Gonadotrophin (H.C.G.) - Treatment of Female Infertility

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Drug: Human Chronic Gonadotrophin (H.C.G.)

What is H.C.G and when is it prescribed

H.C.G. is a hormone manufactured by the early embryo and placenta. It has an effect identical to that of L.H. It is therefore administered at the time of the expected L.H. surge in order to trigger ovulation in an egg brought to maturity by clomiphene.

How is the H.C.G hormone administered

It is given in a dosage of 5,000 (1 ampoule) - 10,000 units by intramuscular injection. Sometimes the luteal phase is still too short in spite of clomiphene in maximum dosage and H.C.G. In such cases, a second H.C.G. injection of 5,000 units is given 7 days after the first H.C.G. This should have the effect of prolonging the luteal phase, thus giving a fertilized egg a better chance of having time to implant in the uterus. However, this second injection can be misleading as patients will see a temperature rise on the B.B.T. Chart that will continue for a few days longer than usual.

What if clomiphene therapy and H.C.G doses fail

10-20% of women fail to conceive on clomiphene and H C.G. In these cases, it will be necessary to consider treatment with Human Menopausal Gonadotrophin, Pergonal. However if P.C.O.D. is present, treatment with pure F.S.H., Metrodin will be indicated.

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