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Drug: Human Chronic Gonadotrophin (H.C.G.) What is H.C.G and when is it prescribed H.C.G. is a hormone manufactured
by the early embryo and placenta. It has an effect identical to that
of L.H. It is therefore administered at the time of the expected
L.H. surge in order to trigger ovulation in an egg brought to maturity
by clomiphene.
How is the H.C.G hormone administered It is given in a dosage of 5,000
(1 ampoule) - 10,000 units by intramuscular injection. Sometimes the luteal
phase is still too short in spite of clomiphene in maximum dosage and H.C.G.
In such cases, a second H.C.G. injection of 5,000 units is given 7 days
after the first H.C.G. This should have the effect of prolonging
the luteal phase, thus giving a fertilized egg a better chance of having
time to implant in the uterus. However, this second injection can be misleading
as patients will see a temperature rise on the B.B.T. Chart that will continue
for a few days longer than usual.
What if clomiphene therapy and H.C.G doses fail 10-20% of women fail to conceive
on clomiphene and H C.G. In these cases, it will be necessary to consider
treatment with Human Menopausal Gonadotrophin, Pergonal. However if P.C.O.D.
is present, treatment with pure F.S.H., Metrodin will be indicated.
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