is possible to genetic testing for diabetes as well. Diabetes is an inherited
disease especially type 1diabetes. The chances of contracting this disease
increase if any of the parents or siblings has this disease. Here are some
facts on genetic testing for diabetes.
Genetic testing is very important in determining the
risk of developing the disease. By identifying the risk factors and the
inherited capability one can prevent the occurrence of diabetes with some
lifestyle changes such as exercises, diet control and so on. Read on to find
more about genetic
testing for diabetes.
What Has Genes
Got to Do With Diabetes?
Type 1 Diabetes
all know that there are two types
of diabetes known as type 1 and type 2. Let us deal with them individually
as we discuss how genetic testing can help in their treatment and prevention.
Genes play a great role as inheritance patterns matter a lot in type 1
genes influence the individualâ€™s risk of contracting the type 1 diabetes. It is
important to note here, one does not inherit the type 1 diabetes in a dominant
or recessive mode. It is particularly the DR3 and DR4 allele along with a
combination of a few other genes that enhances the risk of contracting the
there are genes like the long VNTR regions. Basically, there are around 20
genes that work in alignment with the environmental factors in order to
conclude whether the individual will at all contract the disease.
Genetic Testing Has
a Few Hurdles
the variable factors are extensive, researchers are having a tough time in
determining the exact causative genetic
factors. The gene mutations that are responsible for creating a risk is yet to
be identified. It is perplexing why those with low risk genes like DR2 or DR5
still contract the type 1 diabetes. Thus genetic testing often does not give
other aspect regarding the effectiveness of genetic testing is that the doctors
have not yet developed a treatment course for patients who are considered to be
at high risk following the results of a genetic test.
Testing is Effective on Children
the child has any of his siblings or parents with type 1 diabetes, he is
invariably exposed to the risk of developing the disease sooner or later by
15%. The condition is determined through the HLA type of genetic test along
with whether there are antibodies present in his system.
As for this variant, like type 1, the genetic tests
are conducted by collecting blood samples. A genotype score is charted out for
the individual who is suspected of developing type 2 diabetes. There are 18
different genes that are factors for it.
There is a predictive value of the genotype score
and the researchers arrive at a conclusion after comparing this score with the
predictive value of the said individualâ€™s family history. Then there are also
certain psychological factors too. If most of those 18 genes that are linked to
type 2 diabetes are found to be present in the genotype score, there is a
higher probability of the disease occurring in the person.
According to researchers knowledge and extensive
information about the family history happens to be the most reliable and
effective information cue in assessing whether the individual is exposed to a
diabetes risk or not. The physiological risk assessment is considered to be a
secondary factor. The information are then combined together to arrive at a
Finally, the risk prediction for diabetes is not
yet completely developed. There is a lot more to work on in order to define the
link in an effectively manner. By the current knowledge available with
researchers, genetic testing does not provide with any extra effectiveness. It
merely establishes the suspicion regarding the probability of the person
contracting the disease. Prevention is possible with diet control, exercise and
regular health screenings. The probability cannot be barred even if the
information is available through genetic testing. Only the condition can be
improved through lifestyle checks.